3/29/2024 0 Comments What epidode of grets is scidSelf-shielded gamma irradiators use radioactive sources ( 137Cs or 60Co) that emit gamma radiation at discrete energies due to nuclear decay (0.662 MeV for 137Cs and 1.173/1.332 MeV for 60Co).Small animal research typically employs one of two types of irradiators, gamma or X-ray. Appropriate radiation dosage is the key to the successful irradiation of rodents - excess doses inevitably lead to morbidity, while insufficient doses hinder experimental success and interpretation. These techniques are made possible by specialized research irradiators which deliver precise doses of radiation in a safe and controlled manner. This makes it possible to replace the immune system of an animal with that of a donor, and to study how immune cells regulate transplant rejection, infection, autoimmunity, tumor growth, and more. preventing lethality) with bone marrow or hematopoietic stem cell transplantation. Such radiation doses are often used in conjunction with immunodeficient rodents to inhibit innate immune rejection, particularly by natural killer cells, or to enable the development of chimeric animals expressing several types of hematopoietic cells.Ĭomplete myeloablation is accomplished by giving a lethal dose of radiation, generally followed by rescue of the immune system (i.e. Sublethal radiation renders an animal transiently immunosuppressed this is useful for engrafting tumors or hematopoietic stem cells. The most common application of rodent irradiation is to destroy the bone marrow and other hematopoietic progenitors (myeloablation), either for immunosuppression or before replacing the immune system with donor grafts. Irradiation preferentially kills rapidly dividing cells, including bone marrow and epithelial cells of the gut and other organs. Understanding the biophysical and biological factors involved in irradiation studies is critical for optimizing model performance and improving experimental results.
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